Virtual Histology™

Virtual Histology™ is a new imaging technology that combines proprietary contrast agents, protocols, and software, with microCT imaging. Virtual Histology is establishing the new “gold standard” in soft tissue and skeletal imaging in the preclinical industry for the following reasons:

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  High Resolution - The high resolution images provide high degree of anatomic detail that mimics routine histology as viewed by light microscopy. Virtual Histology can provide greater than 6 µm isometric voxel resolution enabling detailed analysis.
• Bone and Soft Tissue - Numira's virtual histology technology enables the researcher to visualize both soft tissue and skeletal tissue within the same sample to examine morphological differences in knock-out and transgenic preclinical animal models.
  
• Non-Destructive - The digital nature of Numira's technology allows the researcher to easily change the viewing angle from axial, sagittal, coronal, and even arbitrary oblique planes based on the anatomic feature of interest, offering new perspectives – all without sectioning the specimen.  Because the processing does not compromise the sample, upon request the tissue can be returned for further investigation.
• 3D Analysis and Quantification - Numira's segmentation tools enable quantitative analysis of individual organs or other regions of interest in 3D. Some of the routine analyses include linear and volumetric measurements, shape statistics, etc.
• Comprehensive and Accurate - Questionable or insufficient imaging results from other imaging approaches or standard evaluation techniques lead to further investigation and additional research projects and investment.  With our virtual histology technology, the researcher can capture more data and derive more conclusive results than with traditional methods.

Numira's preclinical imaging services provide researchers with their data in a move cost-effective and timely manner, helping to expedite the drug discovery process. Our technologies can be customized to suit the researchers study objectives - from early stage compound screening to pilot toxicology studies to transgenic phenotyping.